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Semenzato, and leveraging our orthogonal experience, we are studying the role of ACLY in B cell differentiation and proliferation in health and disease. The conversion is mediated by ACLY, which has been proven to be important for cell differentiation and stemness, each in physiological and pathological circumstances. However, what determines efflux of citrate from mitochondria just isn’t clear. Using histone acetylation and cell de-differentiation as read-outs, we are interrogating cellular metabolites that may regulate the destiny of mitochondrial citrate. Pancreatic most cancers is characterised by poor total survival and few efficacious therapeutic interventions. One area that has provided vital scope…
